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KMID : 0043319890120040259
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Archives of Pharmacal Research
1989 Volume.12 No. 4 p.259 ~ p.262
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Synthesis and Antimicrobial Activity of Benzofuran-Carboxamide Derivatives
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Hishmat OH
Nasef AM/El Naem SIA/Shalaby AM
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Abstract
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The reaction of the sodium salts of 4-methoxy and 4,7-dimethoxy 6-hydroxybenzofuran-5-carboxylic acid with ethyl chloroformate yields the corresponding dicarbethoxy derivatives. The N-substituted amides were obtained by treating the latter compounds with amines. The corresponding hydrazides were synthesized by the reaction of hydrazine hydrate on the dicarbethoxy derivatives which spontaneously cyclized to 5-substituted-2,3-dihydro-1,3,4-oxadiazol-2-one. Also the reaction with phenyl hydrazine has been studied. The dicarbethoxy derivatives and N-substituted amides were tested against Gram positive and Gram negative bacteria in vitro. Most of the compounds possess moderate or slight activity against Gram positive bacteria.
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